Gender-Specific Dosing of Zolpidem

Several automotive collision reports involving zolpidem were submitted to the FDA, as well as evidence that zolpidem blood levels above 50 ng/mL can impair driving sufficiently to cause a motor vehicle accident. Driving simulation and laboratory studies found that when given a dose of 10 mg zolpidem, 3% of men and 15% of women had zolpidem concentrations above 50 ng/mL eight hours post-dose. Clinical trials also found that a dose of 12.5 mg extended-release zolpidem resulted in zolpidem concentrations >50 ng/mL eight hours post-dose in 33% of women and 25% of men.